Mr Avi Agrawal isConsultant Generalaneral DEAR DOCTORSurgeon practising atSpire Portsmouth HospitalQ Both my mother and veryterrified that I will get it too. Iuntil I find a lump in my breast,recently my sister have hadbreast cancer and I'm absolutely'don't want to sit around and waitwhat can I do?A The lifetime risk of a womandeveloping breast cancer is 1 in 8. Mostof these cancers are not inheritedThere are a very small number ofbreast cancers which may be causedby inheritance of a known faulty gene(BRCA1, BRCA2 or TP53). These tumoursuppressor genes normally produceproteins that can help repair damagedhistory risk assessment is carried out bya healthcare professional.Your motheror sister may already be in the procesof having their genes tested.The family history assessment canbe carried out by a Breast or GeneticsSpecialist or within a specialist familyDNA and therefore play a vital role instabilising each cell's genetic materialWhen either of these genes is mutated, history clinic. They will then be ableor altered, such that its protein product is to determine whether you fall into anot made or does not function correctlygral population, moderate or highDNA damage may not be repairedrisk category.properly. As a result, cells are more likelyIf you fall into a moderate or high riskto develop additional genetic alterations i category, you may be offered enhancedthat can lead to cancer.Testing for these genes can be carried outon blood or saliva samples but shouldonly be considered after a full familyI screening, genetic counselling andgenetic testing. Treatment to reduce therisk can be in the form of medication(chemoprophylaxis) or surgeryTo book a consultation or for any enquiries,please speak to our team onSpirePortsmouth Hospital02392 802 921or email info@spireportsmouth.comBartons Rd, Havant PO9 5NP

Date: 16 May 2018

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Mr Avi Agrawal is Consultant General aneral DEAR DOCTOR Surgeon practising at Spire Portsmouth Hospital Q Both my mother and very terrified that I will get it too. I until I find a lump in my breast, recently my sister have had breast cancer and I'm absolutely ' don't want to sit around and wait what can I do? A The lifetime risk of a woman developing breast cancer is 1 in 8. Most of these cancers are not inherited There are a very small number of breast cancers which may be caused by inheritance of a known faulty gene (BRCA1, BRCA2 or TP53). These tumour suppressor genes normally produce proteins that can help repair damaged history risk assessment is carried out by a healthcare professional.Your mother or sister may already be in the proces of having their genes tested. The family history assessment can be carried out by a Breast or Genetics Specialist or within a specialist family DNA and therefore play a vital role in stabilising each cell's genetic material When either of these genes is mutated, history clinic. They will then be able or altered, such that its protein product is to determine whether you fall into a not made or does not function correctlygral population, moderate or high DNA damage may not be repaired risk category. properly. As a result, cells are more likelyIf you fall into a moderate or high risk to develop additional genetic alterations i category, you may be offered enhanced that can lead to cancer. Testing for these genes can be carried out on blood or saliva samples but should only be considered after a full family I screening, genetic counselling and genetic testing. Treatment to reduce the risk can be in the form of medication (chemoprophylaxis) or surgery To book a consultation or for any enquiries, please speak to our team on Spire Portsmouth Hospital 02392 802 921 or email info@spireportsmouth.com Bartons Rd, Havant PO9 5NP

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